Alcohol consumption and risk of fractures

Alcohol consumption remains inconsistently correlated with fracture risk, but a dose–response meta-analysis for specific outcomes is lacking. A study sought to quantitatively integrate the data on the relationship between alcohol consumption and fracture risk.
Relevant articles were identified in PubMed, Web of Science, and Embase databases up to 20 February 2022. Combined RRs and 95% CIs were estimated. Forty-four articles covering 6,069,770 participants and 205,284 cases of fracture were included. The combined RRs and 95% CIs for highest compared with lowest alcohol consumption were 1.26 (1.17–1.37), 1.24 (1.13–1.35), and 1.20 (1.03–1.40) for total, osteoporotic, and hip fractures, respectively.
A linear positive relationship between alcohol consumption and total fracture risk was detected; the risk was correlated with a 6% increase (RR, 1.06; 95% CI: 1.02, 1.10) per 14 g/d increment of alcohol consumption. J-shaped relationships of alcohol consumption with risk of osteoporotic fractures; and hip fractures were found. Alcohol consumption of 0 to 22 g/d was linked to a reduced risk of osteoporotic fractures and hip fractures.
The findings show that any level of alcohol consumption is a risk factor for total fractures. Moreover, this dose–response meta-analysis shows that an alcohol consumption level of 0 to 22 g/d is related to a reduction in the risk of osteoporotic and hip fractures.
Source: Ke Y, Hu H, Zhang J, Yuan L, Li T, Feng Y, Wu Y, Fu X, Wang M, Gao Y, Huo W, Chen Y, Zhang W, Wang L, Li X, Pang J, Zheng Z, Hu F, Zhang M, Sun L, Zhao Y, Lu J, Hu D. Alcohol consumption and risk of fractures: A systematic review and dose-response meta-analysis of prospective cohort studies. Adv Nutr. 2023 Jul;14(4):599-611. .