Wine consumption and colorectal cancer risk: a meta-analysis of observational studies

There have been inconsistent results in previous research with respect to the correlation between consumption of wine and the development of colorectal cancer (CRC). Scientists carried out a meta-analysis to investigate this issue.
Relevant observational studies were retrieved from a literature search of Embase and Pubmed from inception till 28 February 2017. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated using a random-effects model. A total of eight case-control and nine cohort studies were identified, involving 12110 CRC cases.
The analysis indicated that wine drinking was not associated with any greater risk for CRC (SRR=0.99, 95% CI: 0.89-1.101) when compared with non- drinkers. The subgroup analyses indicated that null
associations were observed in men and women for colon and rectal cancer. Neither light to moderate (<2 drinks/day; SRR=0.93, 95% CI: 0.80-1.08, I=
69.2%) nor heavy (≥2 drinks/day; SRR=1.00, 95% CI: 0.86-1.16, I= 39.9%) consumption of wine was associated statistically with CRC risk.
The researchers state that this meta-analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer.
Source: Wine consumption and colorectal cancer risk: a meta-analysis of observational studies. Xu W, Fan H, Han Z, Liu Y, Wang Y, Ge Z. Eur J Cancer Prev. 2019 May;28(3):151-158.