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The synergy of resveratrol and alcohol against Helicobacter pylori and underlying anti-Helicobacter pylori mechanism of resveratrol
A project investigated the individual antibacterial and synergistic antibacterial effects of resveratrol and alcohol against Helicobacter pylori 26695 in vitro, with the aim to elucidate the underlying mechanism of action of resveratrol against the bacteria.
The minimum inhibitory concentration (MICS) and time-killing curve of resveratrol and alcohol were determined. Transcriptome analysis by RNA- sequencing was used to elucidate the underlying mechanism of action of resveratrol against H. pylori.
The results showed that the MICs of resveratrol and alcohol against H. pylori 26695 are about 64μg/ml and 4% (v/v) respectively. The synergy was found: resveratrol at concentration of 64μg/ ml in combination with alcohol at concentration of 4% (v/v) showed> 10000-fold decrease in the mount of viable bacteria compared with either resveratrol or alcohol used alone. Transcriptome analysis showed 152 genes were downregulated and 111 genes were upregulated in the presence of resveratrol. Genes involved in protein translation
(17·1%), outer membrane proteins (OMPs) (9·9%), and transports (11·2%) comprise 38·2% of the downregulated genes. In comparison, genes involved in redox (13·5%), pathogenesis and motility (9·9%), iron homeostasis (4·5%) comprise 27·9% of the upregulated genes.
A synergy of resveratrol and alcohol against H. pylori was found in the study. The underlying mechanism of action of resveratrol against H. pylori may be mainly attributed to its inhibitory effect on translation, outer membrane proteins, transports, ATP synthase and possible oxidative damage.
The authors state that the study provides a global insight into the anti-H. pylori mechanism of resveratrol. Both resveratrol and alcohol can contribute to inhibition of ribosomes, changes of outer membrane proteins, and oxidative damage, which may be the explanations of synergistic effect against H. pylori elicited by resveratrol and alcohol.
Source: The synergy of resveratrol and alcohol against Helicobacter pylori and underlying anti-Helicobacter pylori mechanism of resveratrol. Xia M, Chen H, Liu S. J Appl Microbiol. 2019 Nov 27.
The minimum inhibitory concentration (MICS) and time-killing curve of resveratrol and alcohol were determined. Transcriptome analysis by RNA- sequencing was used to elucidate the underlying mechanism of action of resveratrol against H. pylori.
The results showed that the MICs of resveratrol and alcohol against H. pylori 26695 are about 64μg/ml and 4% (v/v) respectively. The synergy was found: resveratrol at concentration of 64μg/ ml in combination with alcohol at concentration of 4% (v/v) showed> 10000-fold decrease in the mount of viable bacteria compared with either resveratrol or alcohol used alone. Transcriptome analysis showed 152 genes were downregulated and 111 genes were upregulated in the presence of resveratrol. Genes involved in protein translation
(17·1%), outer membrane proteins (OMPs) (9·9%), and transports (11·2%) comprise 38·2% of the downregulated genes. In comparison, genes involved in redox (13·5%), pathogenesis and motility (9·9%), iron homeostasis (4·5%) comprise 27·9% of the upregulated genes.
A synergy of resveratrol and alcohol against H. pylori was found in the study. The underlying mechanism of action of resveratrol against H. pylori may be mainly attributed to its inhibitory effect on translation, outer membrane proteins, transports, ATP synthase and possible oxidative damage.
The authors state that the study provides a global insight into the anti-H. pylori mechanism of resveratrol. Both resveratrol and alcohol can contribute to inhibition of ribosomes, changes of outer membrane proteins, and oxidative damage, which may be the explanations of synergistic effect against H. pylori elicited by resveratrol and alcohol.
Source: The synergy of resveratrol and alcohol against Helicobacter pylori and underlying anti-Helicobacter pylori mechanism of resveratrol. Xia M, Chen H, Liu S. J Appl Microbiol. 2019 Nov 27.
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