The effect of resveratrol content in red wine on circulating sex hormone-binding globulin

Low sex hormone-binding globulin (SHBG) levels are associated with higher risk of developing cardiovascular disease. Epidemiological studies have shown that red wine has beneficial effects on cardiovascular disease. Researchers explored if resveratrol content in red wine increases SHBG levels.
A pilot study was conducted in 26 healthy volunteers that tested the effect of consuming two types of red wine with different resveratrol content over a 14 day period. SHBG levels and several biochemical parameters were measured at the beginning and the end of every period. Results showed that consumption of both wines did not change body mass index or biochemical markers of liver injury. The low resveratrol wine did not modify the lipid profile or SHBG levels. By contrast, red wine with high resveratrol content significantly reduced total cholesterol in both men and women. Finally, red wine with high resveratrol content increased circulating SHBG in women but not in men.
Red wine rich in resveratrol reduced total cholesterol in men and women and increased SHBG only in women. Further research aimed at investigating the potential SHBG role enhancement mediated by resveratrol regarding cardiovascular protection that presents women in comparison with men seems warranted, the researchers comment.
Source: Briansó-Llort L, Simó-Servat O, Ramos-Perez L, Torres-Torronteras J, Hernandez C, Simó R, Selva DM. Effect of Resveratrol Content in Red Wine on Circulating Sex Hormone-Binding Globulin: Lessons from a Pilot Clinical Trial. Mol Nutr Food Res. 2022 Jun 25:e2200125. doi.org/10.1002/mnfr.202200125.