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The association between age at initiation of alcohol consumption and type 2 diabetes mellitus
Researchers explored the association of age at initiation of alcohol consumption (AAI) and duration of alcohol drinking with type 2 diabetes mellitus among Chinese adults.
The study was based on data from the China Kadoorie Biobank, which included 512,712 participants aged 30-79 years who were living in China in 2004-2008.
The association of AAI and drinking duration with type 2 diabetes was estimated. After adjustment for potential covariates, ages at alcohol initiation (AAIs) of 18.1-29.0 years, 29.1-39.0 years, and >39.0 years were associated with 22% (95% confidence interval (CI): 14, 30), 25% (95% CI: 17, 33), and 32% (95% CI: 24, 39) lower hazards of type 2 diabetes compared with abstaining, respectively. Drinking durations of <10.1 years, 10.1-20.0 years, and 20.1-30.0 years were associated with a lower risk of type 2 diabetes, compared with abstaining.
Among current (weekly) drinkers, AAI <18.1 years and drinking duration >30.0 years were associated with 18% (95% CI: 4, 33) and 20% (95% CI: 3, 40) higher hazards of type 2 diabetes, compared with AAI 18.1-29.0 years and drinking duration <10.1 years, respectively.
In conclusion, late AAI (age at alcohol initiation) and a short drinking duration were associated with a lower risk of type 2 diabetes in this large prospective cohort study of Chinese adults, but early AAI and long drinking duration were not.
Source: Li H, Lv J, Yu C, Guo Y, Bian Z, Fan J, Yang L, Chen Y, Du H, Long H, Zhang Z, Chen J, Chen Z, Huang T, Li L; China Kadoorie Biobank Collaborative Group. The Association Between Age at Initiation of Alcohol Consumption and Type 2 Diabetes Mellitus: A Cohort Study of 0.5 Million Persons in China. Am J Epidemiol. 2020 Dec 1;189(12):1478-1491.
The study was based on data from the China Kadoorie Biobank, which included 512,712 participants aged 30-79 years who were living in China in 2004-2008.
The association of AAI and drinking duration with type 2 diabetes was estimated. After adjustment for potential covariates, ages at alcohol initiation (AAIs) of 18.1-29.0 years, 29.1-39.0 years, and >39.0 years were associated with 22% (95% confidence interval (CI): 14, 30), 25% (95% CI: 17, 33), and 32% (95% CI: 24, 39) lower hazards of type 2 diabetes compared with abstaining, respectively. Drinking durations of <10.1 years, 10.1-20.0 years, and 20.1-30.0 years were associated with a lower risk of type 2 diabetes, compared with abstaining.
Among current (weekly) drinkers, AAI <18.1 years and drinking duration >30.0 years were associated with 18% (95% CI: 4, 33) and 20% (95% CI: 3, 40) higher hazards of type 2 diabetes, compared with AAI 18.1-29.0 years and drinking duration <10.1 years, respectively.
In conclusion, late AAI (age at alcohol initiation) and a short drinking duration were associated with a lower risk of type 2 diabetes in this large prospective cohort study of Chinese adults, but early AAI and long drinking duration were not.
Source: Li H, Lv J, Yu C, Guo Y, Bian Z, Fan J, Yang L, Chen Y, Du H, Long H, Zhang Z, Chen J, Chen Z, Huang T, Li L; China Kadoorie Biobank Collaborative Group. The Association Between Age at Initiation of Alcohol Consumption and Type 2 Diabetes Mellitus: A Cohort Study of 0.5 Million Persons in China. Am J Epidemiol. 2020 Dec 1;189(12):1478-1491.
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