The alcohol–high-density lipoprotein athero-protective axis
An open access review in the journal Biomolecules states that the ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease (ASCVD), an effect that has been attributed to the concurrent elevations of plasma high-density lipoprotein-cholesterol (HDL-C) concentrations. More recent evidence has accrued against the hypothesis that raising plasma HDL concentrations prevents ASCVD so that other metabolic processes associated with alcohol consumption have been considered. The review explored the roles of other metabolites induced by alcohol consumption—triglyceride-rich lipoproteins, non-esterified free fatty acids, and acetate, the terminal alcohol metabolite in athero-protection. Current evidence suggests that acetate has a key role in athero-protection but additional studies are needed, the authors conclude. Source: Rosales, C.; Gillard, B.K.; Gotto, A.M., Jr.; Pownall, H.J. The Alcohol–High-Density Lipoprotein Athero- Protective Axis. Biomolecules 2020, 10, 987.
International Scientific Forum on Alcohol Research
The International Scientific Forum on Alcohol Research (ISFAR) is a group of 45 specialist Professors and Medics who produce balanced and well researched analysis of emerging research papers alcohol and health.