Impact of alcohol dehydrogenase 7 polymorphism and alcohol consumption on risk of head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma is closely associated with alcohol consumption and individual genetic susceptibility, such as single nucleotide polymorphism (SNP) of alcohol dehydrogenase (ADH). A study investigated the association of ADH7 SNPs with the risk of head and neck squamous cell carcinoma.Researchers analyzed ADH7 rs1573496C>G, rs3737482T>C, rs1154460G>A, and rs284787T>C SNPs in 250 patients with head and neck squamous cell carcinoma and 322 controls in the Korean populations. Genotyping was conducted using the TaqMan assay. Linkage disequilibrium and haplotypes were analyzed.
The odds ratios (OR) and 95% confidence intervals (CI) of the CT and CC genotypes of ADH7 rs3737482T>C were 0.48 (0.29–0.78) and 0.69 (0.49–0.96), indicating a significantly decreased risk. In SNP of rs1154460G>A, the OR and 95% CI of the AA genotype was 1.63 (1.11–2.40), showing a significant increase in the risk. Furthermore, SNPs of ADH7 rs3737482T>C and ADH7 rs1154460G>A exhibit synergistic interactions with alcohol composition on the risk of head and neck squamous cell carcinoma. None of the haplotypes were associated with the risk of head and neck squamous cell carcinoma.
In conclusion, ADH7 rs3737482T>C and rs1154460G>A SNPs are associated with the risk of development of head and neck squamous cell carcinoma in Koreans. They could serve as molecular biological markers to screen high-risk groups for head and neck squamous cell carcinoma.
Source: Lee DW, Ji YB, Song CM, Kim JK, Lee SH, Tae K. Impact of Alcohol Dehydrogenase 7 Polymorphism and Alcohol Consumption on Risk of Head and Neck Squamous Cell Carcinoma: A Korean Case-Control Study. J Clin Med. 2023 Jul 13;12(14):4653.