Hongqu rice wines ameliorate high-fat/high-fructose diet-induced metabolic syndrome in rats

A study evaluated the possible protective impact of different vintages of Hongqu rice wines on metabolic syndrome (MetS) in rats induced by high-fat/high-fructose diet (HFFD).
Rats were randomly divided into six groups and treated with (a) basal diet (13.9 kJ/g); (b) HFFD and (c–f) HFFD with 3-, 5-, 8- and 15-year-aged Hongqu rice wines (9.96 ml/kg body weight), respectively, at an oral route for 20 weeks.
Hongqu rice wines could alleviate HFFD-induced augment of body weight gain and fat accumulation, and the release of proinflammatory cytokines. Glycolipid metabolic abnormalities caused by HFFD were ameliorated after Hongqu rice wines consumption by lowering levels of fasting insulin, GSP, HOMA-IR, AUC of OGTT and ITT, and lipid deposition (reduced contents of triglycerides, total cholesterol, free fatty acids, and LDL-Cholestrol, and elevated HDL-Cholestrol level) in the serum and liver. In addition, concentrations of MDA (a biomarker for lipid peroxidation and oxidative stress) and blood pressure markers (ANG-II and ET-1) declined, and activities of antioxidant enzymes (SOD and CAT) were improved in conditions of Hongqu rice wines compared to those in the HFFD group. Eight-year-aged Hongqu rice wine produced a more effective effect on alleviating HFFD-caused MetS among different vintages of Hongqu rice wines.
To conclude, Hongqu rice wines exhibited ameliorative effects on HFFD-induced MetS in rats based on antiobesity, antihyperlipidemic, antihyperglycemic, antioxidant, anti-inflammatory and potential antihypertensive properties.
Source: Nanhai Zhang, Fang Kong, Xiaoxuan Jing, Jingxuan Zhou, Liang Zhao, Mohamed Mohamed Soli-man, Liebing Zhang, Feng Zhou, Hongqu Rice Wines Ameliorate High-Fat/High-Fructose Diet-Induced Metabolic Syndrome in Rats, Alcohol and Alcoholism, 2022;, agac033