Exploring the complex interplay between alcohol consumption and cardiovascular health

A review article explores the intricate relationship between alcohol consumption and cardiovascular health, examining both clinical outcomes and underlying pathophysiological mechanisms. It assesses the complex dose-response relationships for various cardiovascular disease (CVD) subtypes, including coronary heart disease, stroke, and atrial fibrillation, while categorising pathophysiological mechanisms into three conceptual areas: primary initiating factors, secondary transmission pathways, and end-organ effects.
Although mild-to-moderate alcohol consumption may confer some benefits for cardiovascular health and certain CVD subtypes, growing evidence highlights the importance of lifestyle modifications to reduce alcohol intake, particularly among heavy drinkers. The review provides a comprehensive overview of current knowledge, emphasises the need for future research with robust methodologies, and advocates for incorporating updated scientific evidence into personalised approaches within international cardiovascular and national guidelines.
Source: Lee, D.I., Kim, S., Kang, D., O. Exploring the complex interplay between alcohol consumption and cardiovascular health: Mechanisms, evidence, and future directions, Trends in Cardiovascular Medicine, 2025;