Causality between alcohol usually taken with meals and Meniere disease

The recurrence of Meniere disease (MD) strongly affects patient quality of life. Identifying the risk factors for Meniere disease is highly important for its prevention and treatment. Previous studies have suggested that alcohol intake may play a role in the development of MD. However, recent studies have shown that the causal relationship between alcohol consumption and MD remains controversial.
A study used the Mendelian randomization (MR) method to determine the causal relationship between alcohol consumption usually consumed with meals and Meniere disease, with the aim of providing suggestions for alcohol intake management in individuals with Meniere disease and helping in the prevention and treatment of Meniere disease.
Two-sample MR was used to investigate the causal relationship between alcohol usually taken with meals and Meniere disease. A dataset from a publicly available large-scale genome-wide association study (GWAS) was used. Inverse variance weighting (IVW), MR-Egger, simple weighting, weighted weighting and the weighted median method were used for analysis.
The final results showed that IVW results (OR = 0.991, 95% CI: 0.983-0.998, P = .016) suggested that there was statistical significance, but MR-Egger (OR = 0.978, 95% CI: 0.886-1.080, P = .679), weighted median methods (OR = 0.994, 95% CI: 0.985-1.004, P = .307) and Simple mode (OR = 0.995, 95% CI: 0.980-1.010, P = .566), Weighted mode (OR = 0.995, 95% CI: 0.981-1.010, P = .557) found no significant causal relationship. The results suggest that alcohol usually taken with meals may be negatively correlated with MD.
Source: Liu S, Zhang L, Luo W. Causality between alcohol usually taken with meals and Meniere disease: A 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 Feb 16;103(7):e37209.