Cancer risk according to alcohol consumption trajectories: A Population-based cohort study of 2.8 million Korean men

Alcohol drinking behaviours change temporally and can lead to changes in related cancer risks. Previous studies have been unable to identify the association between the two using a single-measurement approach. A study aimed to investigate the association of drinking trajectories with the cancer risk in Korean men.
A trajectory analysis was performed on 2,839,332 men using data on alcohol drinking levels collected three times during the Korean National Health Insurance Service’s general health screening program, conducted between 2002 and 2007. The associations between drinking trajectories and cancer incidence were evaluated, after adjustments for age, income, body mass index, smoking status, physical activity, family history of cancer, and comorbidities.
During 10.5 years of follow-up, 189,617 cancer cases were recorded. Six trajectories were determined: non-drinking, light, moderate, decreasing-heavy, increasing-heavy, and steady-heavy. Light-to-heavy alcohol consumption increased the risk for all cancers combined in a dose-dependent manner (adjusted hazard ratio [aHR] 1.03; 95% confidence interval [CI], 1.02–1.05 for light drinking, aHR 1.06; 95% CI 1.05–1.08 for moderate drinking, aHR 1.19; 95% CI, 1.16–1.22 for decreasing-heavy drinking, aHR 1.23; 95% CI, 1.20–1.26 for increasing-heavy drinking, and aHR 1.33; 95% CI, 1.29–1.38 for steady-heavy drinking). Light-to-heavy alcohol consumption was linked to lip, oral cavity, pharyngeal, esophageal, colorectal, laryngeal, stomach, and gallbladder and biliary tract cancer risks, while heavy alcohol consumption was associated with hepatic, pancreatic, and lung cancer risks. An inverse association was observed for thyroid cancer. The cancer risks were lower for decreasing-heavy drinkers, compared to steady-heavy drinkers.
No safe drinking limits were identified for cancer risks; reduction in heavy intake had protective effects.
Source: Bui TT, Han M, Luu NM, Tran TPT, Lim MK, Oh JK. Cancer Risk According to Alcohol Consumption Trajectories: A Population-based Cohort Study of 2.8 Million Korean Men. J Epidemiol. 2023 Dec 5;33(12):624-632.