Antioxidant and cytotoxic activity of red wine

The beneficial effect of moderate wine consumption is attributed to its micronutrients, especially polyphenols and largely depends on the digestion process. A study aimed to examine the influence of in vitro simulated digestion in the presence of complex food matrix on antioxidant and cytotoxic activity of red wine.
The results showed that total phenolic content of wine sample after in vitro digestion was higher compared to undigested wine, while the antioxidant activity of these samples was similar before and after digestion. Furthermore digested wine showed cytotoxic activity on SKBR3 breast adenocarcinoma cells near 20% after 72h of treatment. This pioneering study that examined biological potential of in vitro digested wine in the presence of complex food matrix indicate that antioxidant and cytotoxic activity of red wine is preserved after digestion.
Source: Đorđević NO, Stanisavljević N, Todorović Vukotić N, Novović K, Žakula JJ, Stanković D, Pajo-vić SB. Antioxidant and cytotoxic activity of red wine after in vitro simulated digestion in the presence of complex food matrix. Nat Prod Res. 2022 Jul 6:1-6. doi.org/10.1080/14786419.2022.2095380.