Alcohol in
Moderation
Moderation
Alcohol intake and incident myocardial infarction: The role of high-density lipoprotein cholesterol
A study tested the hypothesis that the lower risk of myocardial infarction (MI) associated with alcohol intake is through its effect on raising high-density lipoprotein (HDL) cholesterol.
This study included 81,827 Chinese men and women (mean age: 51 ± 12 yr.) from the Kailuan Study who were free of cardiovascular disease in 2006 (at baseline) and were followed up to Dec. 2016. At baseline, alcohol consumption was assessed via a questionnaire and the concentration of HDL cholesterol was measured. Incident MI at follow up was a first MI event, confirmed by medical record review. The association between habitual alcohol intake and risks of MI was modelled, adjusting for age, sex, education, monthly income, occupation, smoking status, physical activity, body mass index, waist circumferences, hypertension, diabetes and total cholesterol.
During an average of 9.6 years of follow-up, 1095 incident cases were documented. The adjusted
hazard ratio (HR) for MI was 0.64 (95% confidence interval (CI), 0.54-0.76) for current alcohol drinkers compared with never or former. The ratio changed very slightly, to 0.65 (95% CI, 0.55- 0.76) after further adjustment of HDL cholesterol concentration. Mediation analysis showed that HDL cholesterol concentrations mediated a small, non-significant proportion (1.8%) of the effect of alcohol on MI.
Alcohol consumption was associated with a lower risk for MI incidence in a large Chinese cohort. These results suggest that the benefits associated with moderate alcohol consumption are not related to the effects of alcohol on HDL cholesterol.
Source: Alcohol Intake and Incident Myocardial Infarc- tion: The Role of High-density Lipoprotein Cholesterol (P18-020-19). Huang S, Huang Z, Shearer G, Li S, Chen S, Wu S, Gao X. Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz039.P18-020-19.
This study included 81,827 Chinese men and women (mean age: 51 ± 12 yr.) from the Kailuan Study who were free of cardiovascular disease in 2006 (at baseline) and were followed up to Dec. 2016. At baseline, alcohol consumption was assessed via a questionnaire and the concentration of HDL cholesterol was measured. Incident MI at follow up was a first MI event, confirmed by medical record review. The association between habitual alcohol intake and risks of MI was modelled, adjusting for age, sex, education, monthly income, occupation, smoking status, physical activity, body mass index, waist circumferences, hypertension, diabetes and total cholesterol.
During an average of 9.6 years of follow-up, 1095 incident cases were documented. The adjusted
hazard ratio (HR) for MI was 0.64 (95% confidence interval (CI), 0.54-0.76) for current alcohol drinkers compared with never or former. The ratio changed very slightly, to 0.65 (95% CI, 0.55- 0.76) after further adjustment of HDL cholesterol concentration. Mediation analysis showed that HDL cholesterol concentrations mediated a small, non-significant proportion (1.8%) of the effect of alcohol on MI.
Alcohol consumption was associated with a lower risk for MI incidence in a large Chinese cohort. These results suggest that the benefits associated with moderate alcohol consumption are not related to the effects of alcohol on HDL cholesterol.
Source: Alcohol Intake and Incident Myocardial Infarc- tion: The Role of High-density Lipoprotein Cholesterol (P18-020-19). Huang S, Huang Z, Shearer G, Li S, Chen S, Wu S, Gao X. Curr Dev Nutr. 2019 Jun 13;3(Suppl 1). pii: nzz039.P18-020-19.
Drinking & You
A global portal providing advice about responsible alcohol consumption, individual country government guidelines and your health.
Go to website
International Scientific Forum on Alcohol Research
The International Scientific Forum on Alcohol Research (ISFAR) is a group of 45 specialist Professors and Medics who produce balanced and well researched analysis of emerging research papers alcohol and health.
Go to website