Alcohol in
Moderation
Moderation
Alcohol consumption and risk of Alzheimer’s disease
Researchers from Jilin City, China investigated the association between alcohol consumption and the risk of Alzheimer’s disease (AD).
PubMed and Web of Science databases were systematically searched as of 1 September 2019 and the association between alcohol consumption and AD risk was evaluated. Subgroup analyses based on the type of alcohol, ethnicity, study design and sex were performed. An alcohol dose-response meta-analysis was carried out. A total of 13 studies were included in the quantitative synthesis, and six were used in the dose-response meta-analysis.
Compared with non-drinkers, individuals who drank had a lower risk of AD (relative risk 0.68, 95% CI 0.53-0.87). In subgroup analyses, drinking wine was found to reduce the occurrence of AD (relative risk 0.71, 95% CI 0.51-0.96). When stratified by ethnicity, sex and study design, no association was seen between AD risk and alcohol use. There was an overall non-linear, but not significant, association between alcohol intake dose and AD risk. A significant non-linear association was observed between excess AD risk and alcohol intake dose in men starting from 14.8 drinks per week. Women’s alcohol intake dose <16.9 drinks per week showed a significant non-linear association with decreased AD risk.
The study concludes that drinking alcohol could reduce the risk of AD. Alcohol dose had a non-linear, but non-significant, relationship with the development of AD. The amount of alcohol consumption showed significant sex-specific effects on AD.
Source: Xie C, Feng Y. Alcohol consumption and risk of Alzheimer’s disease: A dose-response meta-analysis. Geriatr Gerontol Int. 2022 Feb 16.
PubMed and Web of Science databases were systematically searched as of 1 September 2019 and the association between alcohol consumption and AD risk was evaluated. Subgroup analyses based on the type of alcohol, ethnicity, study design and sex were performed. An alcohol dose-response meta-analysis was carried out. A total of 13 studies were included in the quantitative synthesis, and six were used in the dose-response meta-analysis.
Compared with non-drinkers, individuals who drank had a lower risk of AD (relative risk 0.68, 95% CI 0.53-0.87). In subgroup analyses, drinking wine was found to reduce the occurrence of AD (relative risk 0.71, 95% CI 0.51-0.96). When stratified by ethnicity, sex and study design, no association was seen between AD risk and alcohol use. There was an overall non-linear, but not significant, association between alcohol intake dose and AD risk. A significant non-linear association was observed between excess AD risk and alcohol intake dose in men starting from 14.8 drinks per week. Women’s alcohol intake dose <16.9 drinks per week showed a significant non-linear association with decreased AD risk.
The study concludes that drinking alcohol could reduce the risk of AD. Alcohol dose had a non-linear, but non-significant, relationship with the development of AD. The amount of alcohol consumption showed significant sex-specific effects on AD.
Source: Xie C, Feng Y. Alcohol consumption and risk of Alzheimer’s disease: A dose-response meta-analysis. Geriatr Gerontol Int. 2022 Feb 16.
Drinking & You
A global portal providing advice about responsible alcohol consumption, individual country government guidelines and your health.
Go to website
International Scientific Forum on Alcohol Research
The International Scientific Forum on Alcohol Research (ISFAR) is a group of 45 specialist Professors and Medics who produce balanced and well researched analysis of emerging research papers alcohol and health.
Go to website