A systematic review and meta-analysis on the association between alcohol intake and risk of fracture

A systematic review and meta analysis summarised previous studies on the association of alcohol intake with risk of fracture.
A systematic search of research databases was conducted up to November 2020 for studies that were suitable for inclusion. In total, 40 prospective cohort studies including 5,084,303 participants and 170,916 subjects with fracture were included in the review; of them 38 studies with a total sample size of 5,053,117 participants and 169,560 cases of fracture were included in the meta-analysis.
The researchers found a significant positive association between alcohol consumption and risk of total fractures (RR: 1.35; 95% CI: 1.01, 1.81) and any fractures (RR: 1.24; 95% CI: 1.11, 1.38). However, no significant association was observed between alcohol intake and risk of hip fractures (RR: 1.19; 95% CI: 0.96, 1.48), osteoporotic fractures (RR: 2.01; 95% CI: 0.76, 5.34), vertebral fractures (RR: 0.98; 95% CI: 0.68, 1.40), and wrist fractures (RR: 0.99; 95% CI: 0.85, 1.16).
The authors conclude that alcohol consumption was positively associated with risk of total fractures and any fractures. However, they did not observe any significant association between alcohol consumption and risk of hip, osteoporotic, vertebral, and wrist fractures.
Source: Asoudeh F, Salari-Moghaddam A, Larijani B, Esmaillzadeh A. A systematic review and meta-analysis of prospective cohort studies on the association between alcohol intake and risk of fracture. Crit Rev Food Sci Nutr. 2021 Feb 18:1-15.